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January 09, 2009

Volume 284Issue 2p709-e99902
Open Access
On The Cover: Regulation of endothelial nitric-oxide synthase (eNOS) coupling by tetrahydrobiopterin (BH4): immunostaining for human GCH and eNOS-GFP protein expression. Hemagglutinin (HA)-immunoreactive GCH cells (red) counterstained with 4′,6-diamidino-2-phenylindole (DAPI) (blue). eNOS-GFP levels were assessed by fluorescence microscopy (green). We reveal that eNOS:BH4 reaction stoichiometry together with the intracellular BH4:BH2 ratio are the key determinants of eNOS uncoupling, even in the absence of exogenous oxidative stress. For details see the article by Crabtree et al., pages 1136–1144....
On The Cover: Regulation of endothelial nitric-oxide synthase (eNOS) coupling by tetrahydrobiopterin (BH4): immunostaining for human GCH and eNOS-GFP protein expression. Hemagglutinin (HA)-immunoreactive GCH cells (red) counterstained with 4′,6-diamidino-2-phenylindole (DAPI) (blue). eNOS-GFP levels were assessed by fluorescence microscopy (green). We reveal that eNOS:BH4 reaction stoichiometry together with the intracellular BH4:BH2 ratio are the key determinants of eNOS uncoupling, even in the absence of exogenous oxidative stress. For details see the article by Crabtree et al., pages 1136–1144.

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