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March 2022

Volume 298Issue 3
Open Access
On the Cover: Mutational landscape of naturally occurring missense variants in the glucagon receptor found in the human population. Individuals carrying variants causing impairment in cAMP signaling tend to have an increased risk of obesity, increased BMI, and blood pressure. Understanding the functional impact of mutations in the human genome can serve as the first step towards personalized medicine and target-specific drug discovery. Credit to: Alexander Sebastian Hauser and Peter Lindquist (University of Copenhagen). Credit to WOMBO Dream (https://app.wombo.art) for background images. Credit to PyMOL (https://pymol.org/2/) for 3D receptor structure. For details, see the article by van der Velden et al., 101413...
On the Cover: Mutational landscape of naturally occurring missense variants in the glucagon receptor found in the human population. Individuals carrying variants causing impairment in cAMP signaling tend to have an increased risk of obesity, increased BMI, and blood pressure. Understanding the functional impact of mutations in the human genome can serve as the first step towards personalized medicine and target-specific drug discovery. Credit to: Alexander Sebastian Hauser and Peter Lindquist (University of Copenhagen). Credit to WOMBO Dream (https://app.wombo.art) for background images. Credit to PyMOL (https://pymol.org/2/) for 3D receptor structure. For details, see the article by van der Velden et al., 101413
  • Cover

    Published in issue: March 2022
    101841

Editors’ Picks Highlights

JBC Reviews

Accelerated Communications

Methods and Resources

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Genomics and Proteomics

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Plant Biology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

Additions and Corrections

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