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June 2022

Volume 298Issue 6
Open Access
On the Cover: The surface protein Aap mediates intercellular adhesion in Staphylococcus epidermidis biofilms. The B-repeat region of Aap dimerizes in the presence of Zn2+ to form twisted rope-like structures. Recent data reveal that B-repeat dimers (purple/blue structures) further assemble into tetramers via additional Zn2+-binding sites (orange). The tetramer is required for the formation of functional amyloid fibers in the biofilm. Data generated by Alexander Yarawsky; illustration designed by Andrew Herr; biofilm electron micrograph provided by Tammy Gonzalez.For details see the Editors’ Pick article by Yarawsky and Herr, JBC (2020) 295(37):12840-12850...
On the Cover: The surface protein Aap mediates intercellular adhesion in Staphylococcus epidermidis biofilms. The B-repeat region of Aap dimerizes in the presence of Zn2+ to form twisted rope-like structures. Recent data reveal that B-repeat dimers (purple/blue structures) further assemble into tetramers via additional Zn2+-binding sites (orange). The tetramer is required for the formation of functional amyloid fibers in the biofilm. Data generated by Alexander Yarawsky; illustration designed by Andrew Herr; biofilm electron micrograph provided by Tammy Gonzalez.For details see the Editors’ Pick article by Yarawsky and Herr, JBC (2020) 295(37):12840-12850

Editors’ Picks Highlight

JBC Reviews

Accelerated Communications

Methods and Resources

Classics

Bioenergetics

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Genomics and Proteomics

Glycobiology and Extracellular Matrices

Immunology

Lipids

Membrane Biology

Metabolism

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Plant Biology

Protein Structure and Folding

Protein Synthesis and Degradation

RNA

Signal Transduction

Additions and Corrections

Withdrawals/Retractions

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