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January 2023

Volume 299Issue 1
Open Access
On the Cover: Hsp17 is a member of the family of small heat shock proteins in C.elegans. It protects the proteome as a molecular chaperone. In the article by Strauch et al., the structure and mechanism of Hsp17 is reported. The cryo EM structure revealed a sphere composed of 24 subunits shown in the cover as snowflakes. In this structure, 12 of the N-terminal segments are oriented towards the interior while the other 12 point outside. The later ones are engaged in interactions with substrate proteins. The snowflakes represent soluble Hsp17 complexes present in large quantities in the cell. They can also be engaged in insoluble aggregates as shown at the bottom of the figure...
On the Cover: Hsp17 is a member of the family of small heat shock proteins in C.elegans. It protects the proteome as a molecular chaperone. In the article by Strauch et al., the structure and mechanism of Hsp17 is reported. The cryo EM structure revealed a sphere composed of 24 subunits shown in the cover as snowflakes. In this structure, 12 of the N-terminal segments are oriented towards the interior while the other 12 point outside. The later ones are engaged in interactions with substrate proteins. The snowflakes represent soluble Hsp17 complexes present in large quantities in the cell. They can also be engaged in insoluble aggregates as shown at the bottom of the figure
  • Cover

    Published in issue: January 2023
    102919

Editors’ Picks Highlights

JBC Reviews

JBC Communications

Methods and Resources

Meeting Report

Bioenergetics

Cell Biology

Developmental Biology

DNA and Chromosomes

Enzymology

Gene Regulation

Lipids

Membrane Biology

Metabolism

Methods

Microbiology

Molecular Bases of Disease

Molecular Biophysics

Neurobiology

Protein Structure and Folding

Protein Synthesis and Degradation

Research Article Collection: DNA (2022)

Research Article Collection: Molecular Biophysics (2022)

Research Article Collection: Virology (2022)

Signal Transduction

Additions and Corrections

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