February 2023

Cover
Published in issue: February 2023
103015

JBC Reviews

Candidalysin: Connecting the pore forming mechanism of this virulence factor to its immunostimulatory properties
• Charles M. Russell,
• Jennifer A. Rybak,
• Jian Miao,
• Brian M. Peters,
• Francisco N. Barrera
Published online: December 26, 2022
102829

Nucleotide addition and cleavage by RNA polymerase II: Coordination of two catalytic reactions using a single active site
• Ilona Christy Unarta,
• Eshani C. Goonetilleke,
• Dong Wang,
• Xuhui Huang
Published online: December 26, 2022
102844

Regulation and function of the mammalian tricarboxylic acid cycle
• Paige K. Arnold,
• Lydia W.S. Finley
Published online: December 26, 2022
102838

Extracellular chaperone networks and the export of J-domain proteins
• Janice E.A. Braun
Published online: December 25, 2022
102840

Limb blastema formation: How much do we know at a genetic and epigenetic level?
• Sangwon Min,
• Jessica L. Whited
Published online: December 31, 2022
102858

JBC Communications

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry
• Nadia Arang,
• Simone Lubrano,
• Damiano Cosimo Rigiracciolo,
• ...
• Prashant Mali,
• Olivier Harismendy,
• J. Silvio Gutkind
Published online: December 31, 2022
102866

The impact of glucose on mitochondria and life span is determined by the integrity of proline catabolism in Caenorhabditis elegans
• Xi Feng,
• Xinyu Wang,
• Lei Zhou,
• Shanshan Pang,
• Haiqing Tang
Published online: January 06, 2023
102881

Methods and Resources

Monitoring mitochondrial translation by pulse SILAC
• Koshi Imami,
• Matthias Selbach,
• Yasushi Ishihama
Published online: January 02, 2023
102865

Bioenergetics

Cryo-EM analysis of V/A-ATPase intermediates reveals the transition of the ground-state structure to steady-state structures by sequential ATP binding
• Atsuko Nakanishi,
• Jun-ichi Kishikawa,
• Kaoru Mitsuoka,
• Ken Yokoyama
Published online: January 07, 2023
102884

Cell Biology

The 14-3-3γ isoform binds to and regulates the localization of endoplasmic reticulum (ER) membrane protein TMCC3 for the reticular network of the ER
• Saihas Suhda,
• Yasunori Yamamoto,
• Sindhu Wisesa,
• Risa Sada,
• Toshiaki Sakisaka
Published online: December 19, 2022
102813

A novel agonist with homobivalent single-domain antibodies that bind the FGF receptor 1 domain III functions as an FGF2 ligand
• Ryo Yonehara,
• Shigefumi Kumachi,
• Kenji Kashiwagi,
• ...
• Yukio Ueno,
• Naoto Nemoto,
• Masayuki Tsuchiya
Published online: December 16, 2022
102804

Mitochondria-localized lncRNA HITT inhibits fusion by attenuating formation of mitofusin-2 homotypic or heterotypic complexes
• Xingwen Wang,
• Yi Zhang,
• Qingyu Lin,
• Kunming Zhao,
• Dantong Zhu,
• Ying Hu
Published online: December 22, 2022
102825

Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
• Xiaoyan Wang,
• Lijian Shao,
• Kimberly K. Richardson,
• ...
• Daohong Zhou,
• Maria Almeida,
• Ha-Neui Kim
Published online: December 24, 2022
102841

Positive charge in the K-loop of the kinesin-3 motor KIF1A regulates superprocessivity by enhancing microtubule affinity in the one-head–bound state
• Taylor M. Zaniewski,
• William O. Hancock
Published online: December 19, 2022
102818

Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2
• Rachel A. Berg,
• James B. Moseley
Published online: December 23, 2022
102831

Pab1 acetylation at K131 decreases stress granule formation in Saccharomyces cerevisiae
• Sangavi Sivananthan,
• Jessica T. Gosse,
• Sylvain Huard,
• Kristin Baetz
Published online: December 23, 2022
102834

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation
• Takeshi Ikizawa,
• Kazutaka Ikeda,
• Makoto Arita,
• ...
• Tomoyoshi Soga,
• Hidenori Ichijo,
• Isao Naguro
Published online: December 26, 2022
102837

Kinetochore-microtubule attachment in human cells is regulated by the interaction of a conserved motif of Ska1 with EB1
• Renjith M. Radhakrishnan,
• Safwa T. Kizhakkeduth,
• Vishnu M. Nair,
• ...
• Vinesh Vijayan,
• Noriyuki Kodera,
• Tapas K. Manna
Published online: December 30, 2022
102853

Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins
• Elizabeth J. Osterlund,
• Nehad Hirmiz,
• Dang Nguyen,
• James M. Pemberton,
• Qiyin Fang,
• David W. Andrews
Published online: January 02, 2023
102863


SPECC1L binds the myosin phosphatase complex MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin
• Virja Mehta,
• Nathalie Decan,
• Sarah Ooi,
• Antoine Gaudreau-Lapierre,
• John W. Copeland,
• Laura Trinkle-Mulcahy
Published online: January 09, 2023
102893

ADR3, a next generation i-body to human RANKL, inhibits osteoclast formation and bone resorption
• Heng Qiu,
• Christopher Hosking,
• Emel Rothzerg,
• ...
• Kevin Lim,
• Michael Foley,
• Jiake Xu
Published online: January 09, 2023
102889

Ensembles of human myosin-19 bound to calmodulin and regulatory light chain RLC12B drive multimicron transport
• Luther W. Pollard,
• Stephen M. Coscia,
• Grzegorz Rebowski,
• ...
• Erika L.F. Holzbaur,
• Roberto Dominguez,
• E. Michael Ostap
Published online: January 12, 2023
102906

Computational Biology

Molecular dynamics simulations of the calmodulin-induced α-helix in the SK2 calcium-gated potassium ion channel
• Rafael Ramis,
• Óscar R. Ballesteros,
• Arantza Muguruza-Montero,
• ...
• Álvaro Villarroel,
• Aritz Leonardo,
• Aitor Bergara
Published online: December 29, 2022
102850

DNA and Chromosomes

The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins
• Michael M. Soniat,
• Giaochau Nguyen,
• Hung-Che Kuo,
• Ilya J. Finkelstein
Published online: December 15, 2022
102802

Evolution of Rev7 interactions in eukaryotic TLS DNA polymerase Polζ
• Kerry Silva McPherson,
• Alessandro A. Rizzo,
• Heidi Erlandsen,
• Nimrat Chatterjee,
• Graham C. Walker,
• Dmitry M. Korzhnev
Published online: December 30, 2022
102859

Enzymology

pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity
• Kenana Al Adem,
• Juliana C. Ferreira,
• Samar Fadl,
• Wael M. Rabeh
Published online: December 09, 2022
102790

Conformational interdomain flexibility in a bacterial α-isopropylmalate synthase is necessary for leucine biosynthesis
• Yu Bai,
• Wanting Jiao,
• Jan Vörster,
• Emily J. Parker
Published online: December 09, 2022
102789

Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2
• Xiao Liu,
• Raphael Reinbold,
• Shuang Liu,
• ...
• Fraser A. Armstrong,
• Lennart Brewitz,
• Christopher J. Schofield
Published online: January 05, 2023
102873

Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn²⁺ coordination and substrate binding
• Xueqing Du,
• Xuan Chu,
• Ning Liu,
• ...
• Haizhu Yu,
• Fudong Li,
• Chao He
Published online: January 12, 2023
102903


Influenza virus and pneumococcal neuraminidases enhance catalysis by similar yet distinct sialic acid–binding strategies
• Laura Klenow,
• Rageia Elfageih,
• Jin Gao,
• ...
• Stephen G. Withers,
• Jan-Willem de Gier,
• Robert Daniels
Published online: January 09, 2023
102891

Gene Regulation

A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2
• John R. Horton,
• Jujun Zhou,
• Qin Chen,
• Xing Zhang,
• Mark T. Bedford,
• Xiaodong Cheng
Published online: December 31, 2022
102862

Measurement of FGFR3 signaling at the cell membrane via total internal reflection fluorescence microscopy to compare the activation of FGFR3 mutants
• Ingrid Hartl,
• Veronika Brumovska,
• Yasmin Striedner,
• ...
• Gerhard J. Schütz,
• Eva Sevcsik,
• Irene Tiemann-Boege
Published online: December 26, 2022
102832


HSP70 mediates a crosstalk between the estrogen and the heat shock response pathways
• Maruhen Amir Datsch Silveira,
• Fatemeh Khadangi,
• Sofiane Yacine Mersaoui,
• Divya Naik,
• Jean-Yves Masson,
• Steve Bilodeau
Published online: January 04, 2023
102872

Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia
• Ren Ren,
• John R. Horton,
• Qin Chen,
• ...
• Robert M. Blumenthal,
• Xing Zhang,
• Xiaodong Cheng
Published online: January 07, 2023
102885

Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration
• Kevin E.W. Namitz,
• Song Tan,
• Michael S. Cosgrove
Published online: January 06, 2023
102874

Genomics and Proteomics

Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC
• Petra Van Damme,
• Camilla Osberg,
• Veronique Jonckheere,
• ...
• Kris Gevaert,
• Thomas Arnesen,
• Henriette Aksnes
Published online: December 22, 2022
102824

Glycobiology and Extracellular Matrices

Polo-like kinase 1 (PLK1) O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma
• Sheng Yan,
• Bin Peng,
• Shifeng Kan,
• ...
• Xiao Liu,
• Xingzhi Xu,
• Jing Li
Published online: January 07, 2023
102887

AepG is a glucuronosyltransferase involved in acidic exopolysaccharide synthesis and contributes to environmental adaptation of Haloarcula hispanica
• Caixia Pei,
• Hua Lu,
• Jiayin Ma,
• ...
• Hui Zhou,
• Jinghua Yang,
• Cheng Jin
Published online: January 12, 2023
102911

Immunology

TGF-β1 suppresses the T-cell response in teleost fish by initiating Smad3- and Foxp3-mediated transcriptional networks
• Qian Zhang,
• Ming Geng,
• Kang Li,
• ...
• Kete Ai,
• Xiumei Wei,
• Jialong Yang
Published online: December 26, 2022
102843

A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin
• Hina Iqbal,
• Ka Wai Fung,
• Jayesh Gor,
• ...
• George I. Makhatadze,
• Barbara Brodsky,
• Stephen J. Perkins
Published online: December 16, 2022
102799

αβ T-cell receptor recognition of self-phosphatidylinositol presented by CD1b
• Rachel Farquhar,
• Ildiko Van Rhijn,
• D. Branch Moody,
• Jamie Rossjohn,
• Adam Shahine
Published online: December 29, 2022
102849

Role of omega-3 endocannabinoids in the modulation of T-cell activity in a multiple sclerosis experimental autoimmune encephalomyelitis (EAE) model
• Justin S. Kim,
• Katiria Soto-Diaz,
• Tanner W. Bingham,
• Andrew J. Steelman,
• Aditi Das
Published online: January 07, 2023
102886

Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis
• Hannah C. Kondolf,
• Dana A. D'Orlando,
• George R. Dubyak,
• Derek W. Abbott
Published online: January 12, 2023
102908

Lipids

Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice
• Haoya Yao,
• Yaoqing Wang,
• Xiao Zhang,
• ...
• Lin Shang,
• Xiaocui Chen,
• Jia Zeng
Published online: December 27, 2022
102845

Membrane Biology

Charge neutralization of the active site glutamates does not limit substrate binding and transport by small multidrug resistance transporter EmrE
• Peyton J. Spreacker,
• Merissa Brousseau,
• Grant S. Hisao,
• Mohammad Soltani,
• James H. Davis Jr.,
• Katherine A. Henzler-Wildman
Published online: December 15, 2022
102805

Membrane skeleton hyperstability due to a novel alternatively spliced 4.1R can account for ellipsoidal camelid red cells with decreased deformability
• Yuqi Chen,
• Kosuke Miyazono,
• Yayoi Otsuka,
• ...
• Kota Sato,
• Narla Mohandas,
• Mutsumi Inaba
Published online: January 05, 2023
102877

Metabolism

The NTPase activity of the double FYVE domain–containing protein 1 regulates lipid droplet metabolism
• V.A. Ismail,
• T. Naismith,
• D.J. Kast
Published online: December 23, 2022
102830


Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells
• Jake Hsu,
• Nina Fatuzzo,
• Nielson Weng,
• ...
• Benedetta Bigio,
• Carla Nasca,
• Chaitan Khosla
Published online: December 29, 2022
102848

The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes
• Cassandra B. Higgins,
• Joshua A. Adams,
• Matthew H. Ward,
• ...
• Ilona Wandzik,
• Laura G. Schuettpelz,
• Brian J. DeBosch
Published online: December 26, 2022
102835

Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase
• Yoshihiro Morishima,
• Miranda Lau,
• William B. Pratt,
• Yoichi Osawa
Published online: December 31, 2022
102856

Molecular Bases of Disease

An optimized Western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein
• Ilaria Vanni,
• Floriana Iacobone,
• Claudia D’Agostino,
• ...
• Juan Maria Torres,
• Umberto Agrimi,
• Romolo Nonno
Published online: December 21, 2022
102823


How T118M peripheral myelin protein 22 predisposes humans to Charcot–Marie–Tooth disease
• Katherine M. Stefanski,
• Geoffrey C. Li,
• Justin T. Marinko,
• Bruce D. Carter,
• David C. Samuels,
• Charles R. Sanders
Published online: December 26, 2022
102839

A liquid-to-solid phase transition of Cu/Zn superoxide dismutase 1 initiated by oxidation and disease mutation
• Siyu Gu,
• Ming Xu,
• Long Chen,
• Xiangyan Shi,
• Shi-Zhong Luo
Published online: December 30, 2022
102857

Loss of small GTPase Rab7 activation in prion infection negatively affects a feedback loop regulating neuronal cholesterol metabolism
• Pearl Cherry,
• Li Lu,
• Su Yeon Shim,
• ...
• Hermann M. Schatzl,
• Samia Hannaoui,
• Sabine Gilch
Published online: January 06, 2023
102883

Molecular Biophysics

hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (I_Kr) in cardiomyocytes derived from hiPSCs
• Chiamaka U. Ukachukwu,
• Eric N. Jimenez-Vazquez,
• Abhilasha Jain,
• David K. Jones
Published online: December 07, 2022
102778

Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA binding
• Bálint Rehó,
• Lina Fadel,
• Peter Brazda,
• ...
• Katalin Tóth,
• László Nagy,
• György Vámosi
Published online: January 10, 2023
102896

Neurobiology

Intracellular zinc protects Kv7 K⁺ channels from Ca²⁺/calmodulin-mediated inhibition
• Xinhe Yang,
• Shuai Chen,
• Shuo Zhang,
• ...
• Bingcai Guan,
• Nikita Gamper,
• Haixia Gao
Published online: December 19, 2022
102819

Regulatory role of endoplasmic reticulum resident chaperone protein ERp29 in anti-murine β-coronavirus host cell response
• Abhishek Bose,
• Grishma Kasle,
• Rishika Jana,
• ...
• Priyanka Mukherjee,
• Michael Koval,
• Jayasri Das Sarma
Published online: December 23, 2022
102836

Exosomes are involved in iron transport from human blood–brain barrier endothelial cells and are modified by endothelial cell iron status
• Kondaiah Palsa,
• Stephanie L. Baringer,
• Ganesh Shenoy,
• Vladimir S. Spiegelman,
• Ian A. Simpson,
• James R. Connor
Published online: January 02, 2023
102868

Untranslated regions of brain-derived neurotrophic factor mRNA control its translatability and subcellular localization
• Ingrid Lekk,
• Florencia Cabrera-Cabrera,
• Giorgio Turconi,
• ...
• Jaan-Olle Andressoo,
• Tõnis Timmusk,
• Indrek Koppel
Published online: January 10, 2023
102897

Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function
• Patrick J. Kearney,
• Nicholas C. Bolden,
• Elizabeth Kahuno,
• ...
• Gilles E. Martin,
• Gert Lubec,
• Haley E. Melikian
Published online: January 11, 2023
102900

Protein Structure and Folding

The nematode α-catenin ortholog, HMP1, has an extended α-helix when bound to actin filaments
• Erumbi S. Rangarajan,
• Emmanuel W. Smith,
• Tina Izard
Published online: December 17, 2022
102817

Cryo-EM structure of the plant nitrate transporter AtCLCa reveals characteristics of the anion-binding site and the ATP-binding pocket
• Jin He,
• Mingxing Wang,
• Shanshan Li,
• Long Chen,
• Kaiming Zhang,
• Ji She
Published online: December 26, 2022
102833

A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity
• Charlotte M. Fare,
• Kevin Rhine,
• Andrew Lam,
• Sua Myong,
• James Shorter
Published online: December 16, 2022
102806

The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly
• Feng Wang,
• Xiang Feng,
• Qing He,
• Hua Li,
• Huilin Li
Published online: December 30, 2022
102852

5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity
• Kazuhiro Yamada,
• Johnny Mendoza,
• Markos Koutmos
Published online: December 30, 2022
102855

Identification and structural analysis of a carbohydrate-binding module specific to alginate, a representative of a new family, CBM96
• Shiqi Ji,
• Xuhui Tian,
• Xin Li,
• Qunxin She
Published online: December 30, 2022
102854

Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition
• Charly Robert,
• Frédéric Kerff,
• Fabrice Bouillenne,
• ...
• Marylène Vandevenne,
• Patrice Filée,
• André Matagne
Published online: January 12, 2023
102892

HECT domain interaction with ubiquitin binding sites on Tsg101-UEV controls HIV-1 egress, maturation, and infectivity
• David A. Nyenhuis,
• Rohith Rajasekaran,
• Susan Watanabe,
• ...
• Michael Powell,
• Carol A. Carter,
• Nico Tjandra
Published online: January 12, 2023
102901

Protein Synthesis and Degradation

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method
• Ryota Hayashida,
• Reika Kikuchi,
• Kenichiro Imai,
• ...
• Keiji Tanaka,
• Noriyuki Matsuda,
• Koji Yamano
Published online: December 20, 2022
102822

Analysis of a degron-containing reporter protein GFP-CL1 reveals a role for SUMO1 in cytosolic protein quality control
• Wei Wang,
• Jian Lu,
• Wei-Chih Yang,
• Eric D. Spear,
• Susan Michaelis,
• Michael J. Matunis
Published online: December 29, 2022
102851

RanBP9 controls the oligomeric state of CTLH complex assemblies
• Pia Maria van gen Hassend,
• Aparna Pottikkadavath,
• Carolyn Delto,
• ...
• Michelle Endres,
• Lars Schönemann,
• Hermann Schindelin
Published online: January 05, 2023
102869

The penultimate step of proteasomal ATPase assembly is mediated by a switch dependent on the chaperone Nas2
• Suganya Sekaran,
• Soyeon Park
Published online: January 05, 2023
102870

An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response
• Parth H. Amin,
• Kenneth R. Carlson,
• Ronald C. Wek
Published online: December 31, 2022
102864

Assembly chaperone Nas6 selectively destabilizes 26S proteasomes with defective regulatory particle-core particle interfaces
• Jennifer L. Warnock,
• Gabriel W. Jobin,
• Sandhya Kumar,
• Robert J. Tomko Jr
Published online: January 09, 2023
102894

Research Article Collection: Developmental Biology

Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion
• Alicia Wong,
• Samantha Pritchard,
• Mackenzie Moore,
• ...
• Megan Beetch,
• Yoshio Fujitani,
• Emilyn U. Alejandro
Published online: January 06, 2023
102878

Research Article Collection: Membrane Biology

Two Trk/Ktr/HKT-type potassium transporters, TrkG and TrkH, perform distinct functions in Escherichia coli K-12
• Ellen Tanudjaja,
• Naomi Hoshi,
• Kaneyoshi Yamamoto,
• ...
• Masaru Tsujii,
• Yasuhiro Ishimaru,
• Nobuyuki Uozumi
Published online: December 28, 2022
102846

Research Article Collection: Molecular Bases of Disease

Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation
• Goonho Park,
• Ke Xu,
• Leon Chea,
• ...
• Nobuhiko Hiramatsu,
• Jaeseok Han,
• Jonathan H. Lin
Published online: December 20, 2022
102821

Research Article Collection: Molecular Biophysics

Measurements of Na⁺-occluded intermediates during the catalytic cycle of the Na⁺/K⁺-ATPase provide novel insights into the mechanism of Na⁺ transport
• Santiago E. Faraj,
• Wanda M. Valsecchi,
• Mariela Ferreira-Gomes,
• ...
• Juan Pablo FC. Rossi,
• Mónica R. Montes,
• Rolando C. Rossi
Published online: December 17, 2022
102811

Phosphorylation alters the mechanical stiffness of a model fragment of the dystrophin homologue utrophin
• Maria Paz Ramirez,
• Sivaraman Rajaganapathy,
• Anthony R. Hagerty,
• ...
• Joseph M. Muretta,
• Murti V. Salapaka,
• James M. Ervasti
Published online: December 29, 2022
102847

RNA

Comprehensive analysis of RNA-binding protein SRSF2-dependent alternative splicing signature in malignant proliferation of colorectal carcinoma
• Weizhen Liu,
• Dongfang Li,
• Ting Lu,
• ...
• Zihui Zheng,
• Linlin Chen,
• Jun Guo
Published online: January 05, 2023
102876

Signal Transduction

Smad2Δexon3 and Smad3 have distinct properties in signal transmission leading to TGF-β–induced cell motility
• Takashi Yokoyama,
• Takahito Kuga,
• Yuka Itoh,
• ...
• Chiho Omata,
• Masao Saitoh,
• Keiji Miyazawa
Published online: December 19, 2022
102820

Oncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein family member Survivin
• Wen-Hsuan Chang,
• Yinzhe Liu,
• Emma A. Hammes,
• Kirsten L. Bryant,
• Richard A. Cerione,
• Marc A. Antonyak
Published online: December 26, 2022
102842

Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity
• Xiao-Ru Chen,
• Lokendra Poudel,
• Zebin Hong,
• ...
• Fulvia Bono,
• Vytas A. Bankaitis,
• Tatyana I. Igumenova
Published online: January 02, 2023
102861

Combined inhibition of aurora kinases and Bcl-xL induces apoptosis through select BH3-only proteins
• Jian Li,
• Cheng-Hsun Chen,
• Katelyn L. O’Neill,
• ...
• Jennifer D. Black,
• Jingjing Zhang,
• Xu Luo
Published online: January 05, 2023
102875

Dissociation of inositol 1,4,5-trisphosphate from IP₃ receptors contributes to termination of Ca²⁺ puffs
• Holly A. Smith,
• Colin W. Taylor
Published online: January 05, 2023
102871


The store-operated Ca²⁺ channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2
• Joel Nieto-Felipe,
• Jose Sanchez-Collado,
• Isaac Jardin,
• Gines M. Salido,
• Jose J. Lopez,
• Juan A. Rosado
Published online: January 06, 2023
102882

Disruption of the interaction between mutationally activated Gα_q and Gβγ attenuates aberrant signaling
• Jenna L. Aumiller,
• Philip B. Wedegaertner
Published online: January 06, 2023
102880

Additions and Corrections

Correction: Interdomain interactions dictate the function of the Candida albicans Hsp110 protein Msi3
• Hongtao Li,
• Liqing Hu,
• Crist William Cuffee,
• ...
• Qingdai Liu,
• Lei Zhou,
• Qinglian Liu
Published online: January 18, 2023
102879

Correction: Phagocytosis mediated by scavenger receptor class BI promotes macrophage transition during skeletal muscle regeneration
• Jing Zhang,
• Chao Qu,
• Taotao Li,
• Wei Cui,
• Xiaonan Wang,
• Jie Du
Published online: February 01, 2023
102942
Correction: AMP-activated protein kinase α1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation
• Miao Zhang,
• Huaiping Zhu,
• Ye Ding,
• Zhaoyu Liu,
• Zhejun Cai,
• Ming-Hui Zou
Published online: February 08, 2023
102943

Correction: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement
• Rasmus K. Jensen,
• Rasmus Pihl,
• Trine A.F. Gadeberg,
• ...
• Steffen Thiel,
• Nick S. Laursen,
• Gregers R. Andersen
Published online: February 04, 2023
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