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Letters to the Editor
Open Access
LDHA and LDHB are dispensable for aerobic glycolysis in neuroblastoma cells while promoting their aggressiveness
Journal of Biological Chemistry
Vol. 294Issue 1p66Published online: January 1, 2019
- Christian Beltinger
Cited in Scopus: 5
Ždralević et al. (1) show that LDHA and LDHB are redundant in the Warburg effect. These data are in line with recent findings in neuroblastoma cells, where both LDHA and LDHB were found to be dispensable for aerobic glycolysis (2). In contrast to the results of Ždralević et al., however, concomitant depletion of LDHA and LDHB in neuroblastoma cells did not abrogate the Warburg effect. Also in contrast, depletion of either LDHA or LDHB in neuroblastoma cells decreased their aggressiveness, showing that LDHA and LDHB can have cancer-promoting effects independent of aerobic glycolysis.