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Letters to the Editor
Open Access
Reply to Cosgrove: Non-enzymatic action of expansins
Journal of Biological Chemistry
Vol. 295Issue 19p6783Published online: May 8, 2020
- Vivek S. Bharadwaj
- Brandon C. Knott
- Jerry Ståhlberg
- Gregg T. Beckham
- Michael F. Crowley
Cited in Scopus: 0
In our computational study, we use molecular simulations to substantiate a hypothetical mechanism for glycosidic bond cleavage in the presence of a single catalytic acid at the active site of the mutant D10N HiCel45A. In addition to discussing this plausible mechanism from the context of structurally related MltA lytic transglycosylase and subfamily C GH45s, we also suggest the implications of the plausible mechanism for our current understanding of the action of expansins and lytic transglycosylases.