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Letters to the Editor
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Reply to Figueira et al.: Can NAD(P)⁺ transhydrogenase (NNT) mediate a physiologically meaningful increase in energy expenditure by mitochondria during H₂O₂ removal?
Journal of Biological Chemistry
Vol. 296100378Published online: March 15, 2021
- Cody D. Smith
- Cameron A. Schmidt
- Kelsey H. Fisher-Wellman
- P. Darrell Neufer
Cited in Scopus: 2
In our recent publication (1), as well as an earlier publication from our lab (2), we demonstrate under specific experimental conditions designed to increase flux through redox buffering circuits in mitochondria, and thus NADPH demand, that at least a portion of the accompanying increase in JO₂ (i.e., proton conductance) is directly and reproducibly attributed to nicotinamide nucleotide transhydrogenase (NNT; e.g., Fig. 3D in (1)). In their letter to the editor, Figueira et al. question whether flux through redox circuits linked to NNT can mediate a meaningful increase in energy expenditure.