We thank Félix Hernández for his insightful and thoughtful comments as well as interest in our manuscript (1). Regarding suggestion 1, we omitted several glycolytic and gluconeogenic enzymes in the figure for simplicity. We specifically mentioned G6Pase and PEPCK as many investigators have studied these enzymes in particular when studying gluconeogenesis. Articles specifically referenced in our review article studied these two enzymes, and we wished to pictorially represent these enzymes. We further described each of these two enzymes’ specific functions in the text.