Virtual Issue: Methods Madness

Virtual Issue: JBC Methods Madness

This past March, sixteen prominent methods spanning the scope of biological chemistry were matched up, and scientists around the world got to decide which methods advanced to the next round, ultimately crowning #TeamCryo as the first Methods Madness champion. This virtual issue pays homage to the techniques that made it to the later rounds of the tournament by highlighting insights and innovations that have resulted from their application. In particular, we selected some of our recent papers that used cryo-EM/ET, mass spectrometry, CRISPR, PCR or molecular cloning that showcase the creative and versatile application of these methodologies. Moreover, we’ve made the redacted versions of these articles free so you won’t miss a moment. While no collection can capture all of the important methodologies that contribute to the advancement of science, we hope you enjoy this selection of papers as we look forward to next year’s Methods Madness!

The cover art shows representations of our final four methodologies: CRISPR, PCR, mass spectrometry and cryo-EM/ET (clockwise from top left). Cartoons by Vic De Luz. Artwork by Lisa Schnabel.

Assembled by Anand Rao; published May 2020

Find more mass spectrometry papers in our virtual issue on omics of lipids, glycans and polar metabolites.
Find more CRISPR papers in our virtual issue on genome editing.
Browse all previous virtual issues.



Mass Spectrometry

PCR and Molecular Cloning