Artwork by Luciana Giono.
Proteostasis, the dynamic regulation of the proteome to suit cellular requirements, is maintained by the integrated and competing pathways of protein biogenesis, chaperone-assisted folding, trafficking, and degradation. Maintaining proteostasis is critical for normal cell development, healthy aging, and for employing a robust stress response to environmental factors, including assault by pathogens. In contrast, the loss of proteostasis due to protein misfolding and aggregation can cause various neurodegenerative diseases and other proteopathies, including Alzheimer’s, Parkinson’s, Huntington’s, and Creutzfeldt–Jakob diseases.
In this thematic series, we hear from a group of scientists who have reviewed the most recent developments and advances in this exciting field of research.
Assembled by Lila Gierasch and Walid A. Houry (guest); published October 2022