Proteostasis

Proteostasis

Artwork by Luciana Giono.

Proteostasis

Proteostasis, the dynamic regulation of the proteome to suit cellular requirements, is maintained by the integrated and competing pathways of protein biogenesis, chaperone-assisted folding, trafficking, and degradation. Maintaining proteostasis is critical for normal cell development, healthy aging, and for employing a robust stress response to environmental factors, including assault by pathogens. In contrast, the loss of proteostasis due to protein misfolding and aggregation can cause various neurodegenerative diseases and other proteopathies, including Alzheimer’s, Parkinson’s, Huntington’s, and Creutzfeldt–Jakob diseases.

In this thematic series, we hear from a group of scientists who have reviewed the most recent developments and advances in this exciting field of research.

Assembled by Lila Gierasch and Walid A. Houry (guest); published October 2022

Other Thematic Series

Minireview Compendia

All JBC Reviews

  • Arun Kumar, Veena Mathew, Peter C. Stirling
    Preview
  • Mark F. Mabanglo, Walid A. Houry
    Preview
  • Rebecca Mercier, Paul LaPointe
    Preview
  • Gaetano Calabrese, Cristen Molzahn, Thibault Mayor
    Preview
  • Lokha R. Alagar Boopathy, Suleima Jacob-Tomas, Célia Alecki, Maria Vera
    Preview
  • Anna Schaefer, Dalia Naser, Bruna Siebeneichler, Michael V. Tarasca, Elizabeth M. Meiering
    Preview
  • Benjamin Estavoyer, Clémence Messmer, Mohamed Echbicheb, Christopher E. Rudd, Eric Milot, El Bachir Affar
    Preview
  • Cordula Enenkel, Ryu Won Kang, Florian Wilfling, Oliver P. Ernst
    Preview
  • Benjamin S. Rutledge, Wing-Yiu Choy, Martin L. Duennwald
    Preview